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. Author manuscript; available in PMC: 2010 Jan 23.
Published in final edited form as: Neuroscience. 2008 Oct 8;158(2):635–641. doi: 10.1016/j.neuroscience.2008.09.052

Figure 2. The rebound firing post-inhibition is abolished by the T-type calcium channel blocker mibefradil in DCN neurons.

Figure 2

The raster plots show spontaneous activity of individual DCN neurons recorded extracellularly.

A, Photorelease of GABA, at the time indicated by the black triangle, induced a pause followed rebound firing in form of short high frequency burst (marked with a white triangle above the first raster). Bath application of mibefradil (added at the time marked on the left) blocked rebound firing.

B, 10 electrical stimuli @ 100 Hz were delivered at the time indicated by the arrow to activate inhibitory synaptic inputs to a DCN neuron. After the stimulus-induced pause, prominent rebound firing was observed as a high-frequency burst of action potentials (white triangle). The “*”s denote traces in which a clear long lasting increase in firing rate was seen. Bath application of mibefradil (at the indicated time on the left) blocked rebound firing, including the long responses.