. Author manuscript; available in PMC: 2009 Mar 2.

Published in final edited form as: J Allergy Clin Immunol. 2009 Jan;123(1):146–152.e8. doi: 10.1016/j.jaci.2008.10.047

TABLE E1.

National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program criteria for severe asthma in children

Major criteria (must have at least 1)

Daily high-dose ICS

Children <12 y: ≥440 μg fluticasone equivalent/d

Children ≥12 y: ≥880 μg fluticasone equivalent/d

Daily oral corticosteroid use

Minor criteria (must have at least 2)

Treatment with a daily controller medication in addition to ICS

Daily short-acting bronchodilator use (at least 5 of 7 days)

Airway obstruction with FEV₁ <80% predicted at baseline

One or more emergency room visits in the previous 12 mo

Three or more oral corticosteroid bursts in the previous 12 mo

History of worsening symptoms with a reduction in corticosteroid dose

History of intubation