TABLE E7.
Results of univariate linear regression of the percentage of GSSG in the ELF on clinical features of severe asthma*
Dependent variable modeled | Regression coefficient (β) | SE | t | P value | 95% CI |
---|---|---|---|---|---|
FENO† | |||||
% GSSG | 0.012 | 0.005 | 2.320 | .032 | (0.001, 0.022) |
Constant | 1.810 | 0.286 | 6.323 | <.001 | |
ICS dose (μg/d) | |||||
% GSSG | 1.795 | 2.484 | 0.723 | .477 | (−3.332, 6,922) |
Constant | 671.034 | 151.425 | 4.431 | <.001 | |
Baseline FEV1 | |||||
% GSSG | −0.148 | 0.092 | −1.596 | .116 | (−0.333, 0.038) |
Constant | 91.548 | 5.147 | 17.787 | <.001 | |
FEV1 reversibility after bronchodilator (%) | |||||
% GSSG | 0.010 | 0.096 | 0.106 | .917 | (−0.194, 0.214) |
Constant | 11.000 | 5.686 | 1.934 | .072 |
Data are from the combined sample of subjects with severe asthma with and without airway obstruction, excluding adult and pediatric controls.
Data were logarithmically transformed for analysis.