Table 2.
Comparison of efficiency (total repair) and fidelity (correct repair) of MMR at the same DNA site in different conditions*
% total repair (efficiency | ||||||
---|---|---|---|---|---|---|
A | G:T | G:A | G:T | G:A | G:T | G:A |
G1 | 40 | 26 | 30 | 31 | 37 | 35 |
S | 45 | 33 | 55 | 48 | 82 | 59 |
G2/M | 41 | 23 | 37 | 13 | 72 | 40 |
% correct repair (fidelity) | ||||||
B | G:T | G:A | G:T | G:A | G:T | G:A |
G1 | 53 | 30 | 88 | 94 | 94 | 100 |
S | 70 | 40 | 97 | 92 | 96 | 100 |
G2/M | 59 | 80 | 73 | 50 | 91 | 81 |
Nuclear extract; nonreplicating plasmid [10] | Nuclear extract; replicating plasmid (Fig. 4) | Intact cell; replicating plasmid (Fig. 5) |
Total repair and correct repair values only were extracted from each experimental model to condense into Table 2 for comparison purposes.