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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Breast Cancer Res Treat. 2008 Apr 20;114(3):423–431. doi: 10.1007/s10549-008-0024-3

Figure 4. Intralesional injection of MMC with GM-CSF leads to increased MDSC in the spleen while IL-7 and IL-15 did not show such effects.

Figure 4

FVBN202 transgenic mice were inoculated with MMC (4×106 cells/mouse) and received intralesional injection of GM-CSF or IL-7 and IL-15 (1 μg/mouse) after 2 weeks. Control groups received no cytokine treatment. Animals were then sacrificed 4 weeks after the tumor challenge, and presence of CD11b+Gr1+ MDSC in their spleens was assessed by flow cytometry. Representative data are presented from 3 mice per group.