Fig. 7.

Disorazole C₁ causes premature senescence. A549 cells were treated for 7 days with vehicle (DMSO), doxorubicin (DOX; 50 nM), the inactive analog 010A (10 nM), discodermolide (DISCO; 25 nM) vinblastine (VBL; 2 nM), or disorazole C₁ (C₁, 1-10 nM) followed by β-galactosidase staining.