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. Author manuscript; available in PMC: 2009 Nov 28.
Published in final edited form as: Cell. 2008 Nov 28;135(5):838–851. doi: 10.1016/j.cell.2008.09.041

FIGURE 5. Impairment of synaptic transmission in the trpml.

FIGURE 5

(A) Time-course of flies with restored mobility following a 3 min exposure to CO2. n=3, 10 flies per experiment.

(B) Excitatory junctional current (EJC) from the 3rd instar NMJ.

(C) Quantification of the EJC amplitudes in wt and trpml1. n=5 animals; 10 NMJs for each genotype; *, p≤0.001.

(D) NMJ synapses following FM1-43 loading and unloading. Arrows indicate synaptic boutons. Panels below show enlarged magnification of synaptic boutons.

(E) Quantification of FM1-43 fluorescence intensity in NMJ boutons following dye loading and unloading. n=5 animals,10 NMJs for each genotype; *, difference from wt, p≤0.001.

All statistical analyses, t-test.