Table 3.
Effects of DVR with Experimental Variables
| t-test | Multiple Regression with DVR: | |||||||
|---|---|---|---|---|---|---|---|---|
| Sex | Age | Weight | Ketamine timing* | Isoflurane timing* | Injected fallypride | Free fally AUCc | ||
| Mean (SD) | F - 23 M - 10 | 4.09 yrs (± 0.60) | 5.82 kg (± 1.08) | 33 min (± 9) | 27 min (± 9) | 0.31g/kg (± 0.21) | 53pmol/mL·min (± 35) | |
| DVR | p-value | p-values | ||||||
| putamen | 21.8 ± 4.4 19.0 ± 4.2 |
0.26 | 0.22 | 0.41 | 0.57 | 0.53 | 0.98 | 0.65 |
| caudate-head | 17.5 ± 4.2 14.8 ± 4.8 |
0.32 | 0.04 | 0.39 | 0.52 | 0.46 | 0.85 | 0.58 |
| v. stri. | 12.4 ± 2.1 11.4 ± 2.0 |
0.36 | 0.27 | 0.41 | 0.26 | 0.31 | 0.31 | 0.31 |
| pituitary | 3.03 ± 0.86 1.89 ± 0.23 |
0.003 | 0.07 | 0.37 | 0.16 | 0.16 | 0.53 | 0.18 |
| amygdala | 2.67 ± 0.42 2.35 ± 0.38 |
0.07 | 0.02 | 0.41 | 0.56 | 0.45 | 0.14 | 0.18 |
| S.N. | 2.55 ± 0.33 2.33 ± 0.38 |
0.15 | 0.08 | 0.57 | 0.05 | 0.05 | 0.05 | 0.03 |
| thalamus | 2.13 ± 0.39 2.13 ± 0.47 |
0.92 | 0.42 | 0.75 | 0.01 | 0.01 | 0.001 | 0.0004 |
| ant. cing. | 1.76 ± 0.24 1.68 ± 0.21 |
0.52 | 0.21 | 0.42 | 0.63 | 0.51 | 0.57 | 0.47 |
| frontal | 1.49 ± 0.28 1.24 ± 0.13 |
0.30 | 0.72 | 0.09 | 0.61 | 0.50 | 0.11 | 0.027 |
| temporal | 1.46 ± 0.29 1.31 ± 0.23 |
0.26 | 0.18 | 0.09 | 0.70 | 0.95 | 0.26 | 0.06 |
bold – significant when corrected for multiple comparisons
Ketamine (and Isoflurane) timing is the time period between ketamine (isoflurane) administration and the injection of radioligand.