Table III.
Antimicrobial activities of peptides from R. pleuraden skins and their mutants
NA, no activity.
| Antimicrobial activity (MIC)
|
||||
|---|---|---|---|---|
| E. coli | S. aureus | Bacillus subtilis | C. albicans | |
| μg/ml | ||||
| Antioxidin-RP1 | NA | NA | NA | NA |
| M2G-antioxidin-RP1 | NA | NA | NA | NA |
| Y6G-antioxidin-RP1 | NA | NA | NA | NA |
| Y12G-antioxidin-RP1 | NA | NA | NA | NA |
| P9G-antioxidin-RP1 | NA | NA | NA | NA |
| C10G-antioxidin-RP1 | NA | NA | NA | NA |
| M2G/Y6G/Y12G/P9G/C10G-antioxidin-RP1 | NA | NA | NA | NA |
| Pleurain-A1 | 60 | 15 | 120 | 30 |
| M5G-pleurain-A1 | 60 | 15 | 120 | 30 |
| P12G-pleurain-A1 | 120 | 15 | 120 | 60 |
| W15G-pleurain-A1 | 120 | 30 | 120 | 60 |
| Y23G-pleurain-A1 | 30 | 15 | 60 | 15 |
| M5G/P12G/W15G/Y23G-pleurain-A1 | 120 | 15 | 120 | 30 |
| Pleurain B1 | 25 | 3.1 | 3.1 | 1.6 |
| Pleurain C1 | 50 | 6.3 | 3.1 | 25 |
| Pleurain D1 | 25 | 12.5 | 50 | 25 |
| Pleurain-D4 | 50 | 12.5 | 50 | 25 |
| P13G-pleurain-D4 | 50 | 25 | 50 | 25 |
| Pleurain E1 | 25 | 6.3 | NA | 25 |
| W4G-pleurain-E1 | 50 | 12.6 | NA | 25 |
| P7G/P8G/P12G/P16G/P24G-pleurain-E1 | 25 | 12.6 | NA | 50 |
| C23G-pleurain-E1 | 25 | 3.2 | NA | 25 |
| W4G/P7G/P8G/P12G/P16G/P24G/C23G-pleurain-E1 | 50 | 6.3 | NA | 50 |
| Pleurain G1 | 50 | 50 | 100 | 12.5 |
| W3G-pleurain-G1 | 100 | 50 | 100 | 12.5 |
| P29G/P30G-pleurain-G1 | 50 | NA | 100 | 25 |
| W3G/P29G/P30G-pleurain-G1 | 100 | NA | 100 | 25 |
| Pleurain J1 | 12.5 | 12.5 | 50 | 6.3 |
| P3G/P14G/P24G/P25G-pleurain-J1 | 12.5 | 12.5 | 100 | 12.5 |
| C18G-pleurain-J1 | 6.3 | 6.3 | 50 | 6.3 |
| P3G/P14G/P24G/P25G/C18G-pleurain-J1 | 12.5 | 12.5 | 100 | 6.3 |
| Pleurain K1 | NA | NA | NA | NA |
| P3G-pleurain-K1 | NA | NA | NA | NA |
| M7G-pleurain-K1 | NA | NA | NA | NA |
| W10G-pleurain-K1 | NA | NA | NA | NA |
| P3G/M7G/W10G-pleurain-K1 | NA | NA | NA | NA |
| Pleurain M1 | 6.3 | 6.3 | 25 | 12.5 |
| P30G-pleurain M1 | 6.3 | 6.3 | 25 | 12.5 |
| Pleurain N1 | 50 | 12.5 | NA | 12.5 |
| C23G-pleurain-N1 | 25 | 12.5 | NA | 6.3 |
| P26G/P29G/P30G-pleurain-N1 | 100 | 25 | NA | 12.5 |
| C23G/P26G/P29G/P30G-pleurain-N1 | 50 | 25 | NA | 25 |
| Pleurain P1 | NA | NA | NA | NA |
| Y24G-pleurain-P1 | NA | NA | NA | NA |
| P27G/P36G-pleurain-P1 | NA | NA | NA | NA |
| Y24G/P27G/P36G-pleurain-P1 | NA | NA | NA | NA |
| Pleurain R1 | 100 | 25 | 100 | 50 |
| W4G-pleurain-R1 | 100 | 12.5 | 100 | 50 |
| M5G-pleurain-R1 | 100 | 12.5 | 100 | 50 |
| P16G-pleurain-R1 | 200 | 25 | 200 | 50 |
| W4G/M5G/P16G-pleurain-R1 | 200 | 25 | 100 | 50 |