Table 3.
Age- and smoking-matched and fully adjusted risk of future cardiovascular disease for three threshold cutpoints of interleukin-18. Cutpoints were established based on the interleukin-18 distribution in the control population. The reference group for this analysis includes all subjects with IL-18 levels below the specified cutpoint.
| Age and Smoking Matched* |
Fully Adjusted† |
||||||
|---|---|---|---|---|---|---|---|
| Cutpoint (percentile) | IL-18 Value (pg/mL) | Number of Controls (%) | Number of Cases (%) | RR | P-value | RR | P-value |
| ≥ 75th | 307.5 | 64 (25) | 104 (41) | 2.00 (1.37–2.92) | 0.003 | 1.46 (0.84–2.53) | 0.18 |
| ≥ 90th | 442.0 | 26 (10) | 50 (20) | 2.20 (1.30–3.73) | 0.004 | 2.41(1.05–5.56) | 0.04 |
| ≥ 95th | 549.3 | 13 (5) | 27 (11) | 2.40 (1.15–5.02) | 0.02 | 2.20 (0.81–5.97) | 0.12 |
Age and smoking matched model is equivalent to Model 1 in Table 2.
The fully adjusted RR is age and smoking matched and further adjusted for diabetes (yes/no), body mass index (kg/m2), blood pressure (Framingham categories), hormone therapy use at the time of blood sampling, a parental history of myocardial infarction at age < 60 years, total cholesterol (mg/dL), high-density lipoprotein cholesterol (mg/dL) and randomized treatment assignment. It is equivalent to Model 3 in Table 2.