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Immunohistochemical staining for E-cadherin. E-cadherin is an epithelial cell marker. E-cadherin was widely expressed in distal tubular and collecting duct epithelial cells of normal kidneys (A, × 200). In ADPKD kidneys, the E-cadherin expression pattern was heterogeneous; there were portions in cystic epithelial cells of large renal cysts with decreased expression (B, × 200, C and D, × 400). ADPKD, autosomal dominant kidney disease.
