Table 2.
Mitochondrial DNA, Complex I and Complex IV Values in Subcutaneous Fat and in PBMCs by Cohorta
| |
Subcutaneous adipose tissue |
PBMCs |
||||
|---|---|---|---|---|---|---|
| HIV− | Nonlipoatrophic | Lipoatrophic | HIV− | Nonlipoatrophic | Lipoatrophic | |
| N | 7 | 4 | 15 | 7 | 4 | 15 |
| mtDNA copies/cell (% of value in HIV−) | 1739*,† | 412 | 507* | 178 | 144 | 170 |
| Median | (572–2848) | (236–577) | 165–867) | (112–338) | (119–184) | (97–297) |
| Range | (100%) | (24%) | (29%) | (100%) | (81%) | (96%) |
| Complex I optical density units | ||||||
| Median | 41,300† | 21,400 | 29,600† | 129,200† | 129,400 | 89,800† |
| Range | (28,000–93,000) | (14,300–74,900) | (6,500–41,100) | (88,000–140,000) | (67,000–143,000) | (79,000–126,300) |
| (% of value in HIV−) | (100%) | (52%) | (72%) | (100%) | (100%) | (70%) |
| Complex IV optical density units | ||||||
| Median | 545,000† | 421,600 | 305,800† | 129,200† | 148,900† | 90,100†,‡ |
| Range | (394,000–606,600) | (257,200–765,000) | (34,400–544,500) | (62,000–261,000) | (104,200–169,300) | (25,500–212,400) |
| (% of value in HIV−) | (100%) | (77%) | (56%) | (100%) | (115%) | (70%) |
a
The range in values is presented in parentheses. Values with the same superscript are significantly different by Mann–Whitney test: *p ≤ 0.001 and †,‡p ≤ 0.05.