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EGF inhibits the TCDD-mediated increase in transcription. Levels of CAT activity (mean ± SD, n = 4–5) are expressed in units relative to the control treatment (without EGF and TCDD), given a value of 1; pCAT3 basic, pCAT3b; pCAT promoter, pCATp. Xenobiotic-responsive elements (XREs) in the constructs are indicted by the letter x. The a indicates that the value from treatment with TCDD and EGF is significantly different from value with TCDD and without EGF; P < 0.05 by Student's t test.
