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Engineered ϕlexA3 bacteriophage enhances killing of quinolone-resistant E. coli RFS289 bacteria by ofloxacin. Killing curves for no phage (black diamonds), unmodified phage ϕunmod (red squares), and engineered phage ϕlexA3 (blue circles) with 1 μg/ml ofloxacin (oflox). 108 pfu/ml phage was used. ϕlexA3 greatly enhanced killing by ofloxacin by 1 h of treatment.
