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Precocious meiotic resumption of oocytes cultured with Src inhibitor.
| Exposure Time | N | %GVBD | %MII |
|---|---|---|---|
| 5h cAMP | 10 | 0a | 100c |
| 5h SKI+cAMP | 43 | 60b | 93c |
Oocytes cultured with the Src inhibitor and dbcAMP resumed meiosis and initiated GVBD while control oocytes remained arrested at GV (a,b) P>0.05. Following wash-out from the dbcAMP both control and SKI606 treated oocytes matured to MII(c) P>0.05.
