Table 4.
Gene sets enriched in hippocampal cell layers.
| GENE SET NAME | SIZE | CORE | p-value | FDR | CLASS |
|---|---|---|---|---|---|
| Enriched in CA1 | |||||
| ANDROGEN_GENES_FROM_NETAFFX | 15 | 8 | 0.006 | 0.11 | |
| RAR_UP | 15 | 5 | 0.018 | 0.06 | |
| VEGFPATHWAY | 15 | 5 | 0.017 | 0.08 | |
| AR_ORTHOS_MAPPED_TO_U133_VIA_NETAFFX | 17 | 4 | 0.035 | 0.14 | |
| AR_MOUSE | 17 | 4 | 0.035 | 0.11 | |
| Enriched in CA3 | |||||
| CR_PROTEIN_MOD | 45 | 11 | 0.002 | 0.24 | |
| ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY | 15 | 6 | 0.018 | 0.16 | |
| PPARAPATHWAY | 21 | 5 | 0.004 | 0.21 | Met |
| KRAS_TOP100_KNOCKDOWN | 23 | 4 | 0.023 | 0.17 | |
| INSULIN_2F_UP | 71 | 21 | 0.000 | 0.14 | Met |
| SIG_INSULINRECEPTORPATHWAYINCARDIACMYOCYTES | 23 | 7 | 0.014 | 0.19 | Met |
| MAP00010_GLYCOLYSIS_GLUCONEOGENESIS | 17 | 14 | 0.039 | 0.21 | Met |
| Enriched in DG | |||||
| HOXA9_DOWN | 17 | 3 | 0.002 | 0.09 | Tr |
| CR_CELL_CYCLE | 24 | 6 | 0.004 | 0.19 | |
| P38MAPKPATHWAY | 16 | 9 | 0.015 | 0.20 | MAP |
| HUMAN_CD34_ENRICHED_TF_JP | 41 | 22 | 0.002 | 0.15 | Tr |
| MAPKPATHWAY | 34 | 17 | 0.031 | 0.26 | MAP |
| DNA_DAMAGE_SIGNALLING | 21 | 4 | 0.039 | 0.23 | Tr |
GSEA of hippocampal cell layers. Geneset name is from MSigDB 1.0. Size is the number of genes from the geneset that are expressed in our dataset. Core is the number of genes in the ‘leading edge’ of the gene set; a higher ratio of core to total genes indicates a more robust enrichment. P-value and False Discovery Rate are measures of the significance of the enrichment in one region as compared to the other two. Seceral broad classes of gene sets were prominently represented: Transcription and MAPK signaling in DG and Metabolism of glucose in CA3.