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. Author manuscript; available in PMC: 2010 Jan 15.
Published in final edited form as: Free Radic Biol Med. 2008 Nov 1;46(2):220–231. doi: 10.1016/j.freeradbiomed.2008.10.025

Figure 8. Cinnamic aldehyde inhibits TNFα-induced expression of IL-8 in A375 melanoma cells.

Figure 8

A375 cells were pretreated with CA for 3 h and then exposed to TNFα. After 6 h, IL-8 expression was examined in CA- and mock-pretreated cells by flow cytometric analysis using an Alexa 488-conjugated mouse monoclonal antibody directed against human IL-8. (A) Modulation of IL-8 expression by CA (20 μM) pretreatment followed by TNFα stimulation. (B) Dose response relationship of inhibition of TNFα-induced IL-8 expression by CA (10 and 20 μM) pretreatment. One representative experiment out of at least three similar repeats is shown.