Figure 3.

Engagement of the BCR by self-antigens cannot rescue the development of Syk-deficient B cells. (A) Development of syk+/− and syk−/− Ig^HEL B cells in the absence of autoantigen (none) or the presence of sHEL or mHEL. Data were obtained and presented as in Fig. 1. The result from the single Ig^HEL syk+/− mHEL chimera is representative of published data (21, 22). (B). Numbers of B220-positive syk+/− and syk−/− Ig^HEL cells in the absence of autoantigen or the presence of sHEL or mHEL. Histograms show arithmetic means and dots represent individual chimeras.