Table 2.
Structures and IC50 values for 19 synthetic compounds that are strong inhibitors of vaccinia DNA synthesis in vitroa
| Librarya | Compound Structure | DNA Synthesis IC50 (∞M) |
|---|---|---|
| 1 |  |
0.5 |
| 5 |  |
1.3 |
| 1 |  |
3.0 |
| 1 |  |
3.5 |
| 3 |  |
3.8 |
| 1 |  |
4.0 |
| 1 |  |
4.1 |
| 4 |  |
5.0 |
| 4 |  |
5.3 |
| 1 |  |
5.4 |
| 1 |  |
5.9 |
| 1 |  |
6.0 |
| 3 |  |
6.3 |
| 1 |  |
6.7 |
| 1 |  |
7.3 |
| 1 |  |
7.4 |
| 4 |  |
7.4 |
| 1 |  |
10 |
| 1 |  |
10 |
a
These compounds do not have favorable antiviral activity in cell-based assays since they are either highly toxic or failed to block viral infection.
b
The synthetic compounds belong to the following libraries: ChemDiv 3 (library 1); Maybridge 4 (library 3); ActiMol TimTec (library 4); and Bionet 2 (library 5).