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. 2009 Jan 21;106(7):2230–2235. doi: 10.1073/pnas.0812880106

Fig. 2.

Fig. 2.

Ier2 and Fibp1 are required for convergent extension. Control (A and B) and ier2 morphant (C and D). Lateral (A and C) and dorsal (B and D) views at the 5-somite stage. Brackets in A and C show the distance between head and tail, and arrowheads in B and D show the width of the somites. (E–L) Two-color in situ hybridization with marker genes at the 3-somite stage. Dorsal views of anterior (E–H) and posterior (I–L) region. (E and I) Drawings of a normal embryo indicating the patterns of the markers used, ctsl1b (red), dlx3b (blue), ntl (blue), and pcdh8 (red). (F and J) Control MO-injected embryo. (G and K) ier2 MO-injected embryo. (H and L) fibp1 MO-injected embryo. In the experimental embryos, notochord and somites are wider and extension along the A/P axis is reduced.