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. 2009 Jan 23;106(7):2319–2324. doi: 10.1073/pnas.0806383106

Fig. 3.

Fig. 3.

Relationship between the expression of miRNAs and their predicted mRNA targets in airway epithelium of current and never smokers. The distribution of Pearson correlation coefficients calculated between the miRNA and predicted target mRNA expression for 6 of the 28 differentially expressed miRNAs is shown in red. All 232 miRNAs and their predicted targets are in black. There is a significant increase in the degree of negative correlation between differentially expressed miRNAs and their targets relative to all miRNAs and their targets, which reflects the inhibitory effects of miRNAs on target gene expression. These 6 miRNAs have the highest number of predicted mRNA targets with significantly anticorrelated expression in vivo.