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. 2009 Jan 23;106(7):2319–2324. doi: 10.1073/pnas.0806383106

Fig. 5.

Fig. 5.

Overexpressing mir-218 attenuates the induction of MAFG expression by cigarette smoke condensate in NHBE. CSC induces MAFG expression 1.54-fold (Scrambled + DMSO vs. Scrambled + CSC). However, when mir-218 is overexpressed, CSC induces MAFG expression only 1.11-fold (mir-218 + CSC vs. mir-218 + DMSO). The significantly reduced induction of MAFG by cigarette smoke condensate in the presence of high levels of mir-218 (2-way ANOVA interaction effect, P = 0.000003) suggests that modulation of mir-218 contributes to the CSC-dependent regulation of MAFG expression.