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LPMycN/+ and LPMycN/N mice develop pro-B cell lymphomas. (A) Kaplan–Meier curves of the LPMycN/+ (n = 21) and LPMycN/N (n = 9) cohorts are shown. The curves represent tumor-free survival. (B) Surface marker expression in LPMycN/+ and LPMycN/N tumors was analyzed by cytofluorimetry with B220/IgM (Top) or CD4/CD8 (Bottom) antibodies. C, control; spl, spleen; pLN, peripheral lymph nodes; thy, thymus. Representative cases are shown.
