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. 2009 Jan 27;106(7):2265–2270. doi: 10.1073/pnas.0812763106

Fig. 3.

Fig. 3.

LPMycN/+ and LPMycN/N tumors harbor characteristic c12;15 and t12;15 translocations. (A) FISH and chromosome paint analysis of metaphases from selected LPMycN/+ and LPMycN/N tumors. The same metaphase was sequentially analyzed with a different set of probes as indicated at the top of each panel. Note that the red signal from the second hybridization was not efficiently stripped and still shows in the third set of images. Results from chromosome paint hybridization were confirmed on an independent set of metaphases for all tumors analyzed (not shown). A schematic of the different chromosomal species detected is shown at the Top. (B) Summary of FISH and chromosome paint analyses on additional LPMycN/+ tumors. Only chromosomes involved in translocations are shown. Sequential hybridization with the set of probes indicated at the top was performed. A graphic representation of the translocations observed in each case is shown.