Fig. 1.

Cyclo expands lifespan in the npc1^−/− mouse. (A) Npc1^−/− mice continuously fed ezetimibe, which markedly lowers cholesterol flux into the liver and improves liver function, did not live longer than those animals not fed this compound. (B) A single dose of CYCLO 4.5 or 5.6 administered at 7 days of age did, however, significantly and equally prolong life. (C) Addition of Allo to either the CYCLO 4.5 or CYCLO 5.6 did not significantly further prolong life (number indicated for each group). In each experiment, the untreated control animals were littermates of the treated group.