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Comparison of phenotypes between transgenic and knock-in mouse models of HD and human patients. Transgenic YAC mice express human mHTT with its regulatory sequences and exhibit an earlier and more severe phenotype than knock-in mice, which express the CAG expansion in the context of the mouse Htt gene. References: *Graham et al., 2006; †Slow et al., 2003; #Van Raamsdonk et al., 2005b; §Lerch et al., 2008; **Heng et al., 2007; ††Pouladi et al., 2009; ##Tang et al., 2007.
