Table 2.

Protein sequence elements that do not differ between human and mouse HTT

Functional site	Location*	References
Caspase-6 cleavage	IVLD 586	Wellington et al., 2000
Caspase-2/3 cleavage	DLND 552	Hermel et al., 2004
Caspase-3 cleavage	DVSD 513	Wellington et al., 2000
Palmitoylation	C214	Yanai et al., 2006
Phosphorylation	S421	Warby et al., 2005
Calpain cleavage	VLS 438	Gafni and Ellerby, 2002
	SSS 537
Aspartyl protease cleavage	HCLT…NIVA 104–114	Lunkes et al., 2002
	RMVA…LLPC 146–214
Sumoylation, ubiquitylation	K6, K9, R15	Steffan et al., 2004
Proteasome-targeting sequences	FQKLL 127	Chandra et al., 2008
Nuclear export signal	IIIS…RLPL 2397–2406†	Xia et al., 2003
Putative nuclear localisation signal	PIRR…KEKE 1182–1191	Bessert et al., 1995
Membrane-associated domain/cytoplasmic retention signal	MATL…LKSF 1–17	Steffan et al., 2004; Truant et al., 2006

^*Motif sequence and position of the last residue in the motif in human HTT NP_002102, or sequence range for motifs >6 residues.

^†The nuclear export signal has two conservative Ile to Val changes between the human and mouse.