Table 2.
Serum total T4 (μg/dl), serum TSH (μg/ml), and radioactive iodine uptake (RAIU, in cpm/mg thyroid) in thyr-IFN-γ transgenic and control mice
| Line A
|
Line B
|
Line C
|
||||
|---|---|---|---|---|---|---|
| Control | Transgenic | Control | Transgenic | Control | Transgenic | |
| Serum total T4 | ||||||
| Mean ± SD | 5.58 ± 1.50** | 2.78 ± 1.36 | 5.34 ± 0.93 | 5.14 ± 1.71 | 5.83 ± 1.21** | 2.39 ± 1.25 |
| No. of mice | 50 | 53 | 37 | 38 | 27 | 35 |
| Serum TSH | ||||||
| Mean ± SD | 0.162 ± 0.06§§ | 9.09 ± 3.12 | 0.15 ± 0.05 | 0.13 ± 0.07 | 0.14 ± 0.04§§ | 15.28 ± 5.83 |
| No. of mice | 5 | 6 | 5 | 5 | 5 | 5 |
| RAIU | ||||||
| Mean ± SD | 1,757,340 ± 244,358* | 318,257 ± 188,052 | 1,537,821 ± 234,679 | 1,724,317 ± 203,120 | ||
| No. of mice | 4 | 10 | 4 | 9 | Not done | Not done |
**, P < 0.0001, when comparing by unpaired t test in each line the means of total T4 in transgenics and controls. §, P < 0.01 and §§, P < 0.001, when comparing in each line the THS and RAIU means of transgenics and controls by Mann–Whitney test.