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. Author manuscript; available in PMC: 2009 Mar 3.
Published in final edited form as: Mol Psychiatry. 2008 May 27;13(8):800–812. doi: 10.1038/mp.2008.59

Figure 4.

Figure 4

Schematic of sites where variations in TBX21 or PSMB4 could influence the T-cell arm of the adaptive immunity and contribute to susceptibility to major depressive disorder (MDD): Two crucial functions, specifically antigen processing and T cell-programmed differentiation are involved in Mexican Americans with MDD and are highlighted in red. A naive helper T-cell precursor (Th p) can become either a Th1 or Th2 cell under the instructive influence of interleukin-12 (IL-12) or IL-4, respectively; Th1 cell expresses TBX21 and Th2 expresses GATA3.