. Author manuscript; available in PMC: 2009 Mar 3.

Published in final edited form as: Mol Psychiatry. 2008 May 27;13(8):800–812. doi: 10.1038/mp.2008.59

Table 3.

Combined effect of TBX21 and PSMB4 genes on the risk of depression

OR by total risk allele no.^a				OR by combined genotype^b
No. of risk allele	Case/control	OR (95% CI)	P	rs17244587	rs2296840	Case/control	OR (95% CI)	P
0	57/93	1.00	-	GG	CC/TC	133/154	1.00	-
1	123/88	2.28 (1.49-3.50)	0.0002	GG	TT	19/8	2.75 (1.17-6.49)	0.02
2	58/30	3.15 (1.82-5.47)	0.00004	AG/AA	CC/TC	90/49	2.13 (1.40-3.23)	0.0004
3	12/2	9.79 (2.11-45.3)	0.004	AG/AA	TT	8/2	4.63 (0.97-22.2)	0.05

Sum of risk alleles at rs17244587 (AA = 2, AG=1, GG = 0) and rs2296840 (TT = 2, TC = 1, CC = 0); Cochran-Armitage trend test: Z = -5.095, d.f. = 1, P = 1.74-E7; PAF = 47.8%.

Rothman synergy index= (4.63-1)/(2.75 + 2.13-2) = 1.26.