Table 4.

Polymorphisms associated with response status in the treatment of depression

							Minor allele frequency
Medication	Gene	SNP	Chromosome	Position	SNP type	Minor/major allele	Responder	Nonresponder	or (95% CI)a	Pa
Desipramine or Fluoxetine	UCN3	rs10904481	10	5405954	Missense	G/A	0.431	0.586	0.53 (0.30, 0.97)	0.04
	CD3E	rs2231449	11	117691515	3′ UTR	A/C	0.015	0.083	0.17 (0.04, 0.72)	0.007
	PSMD9	rs1043307	12	120838179	Missense	G/A	0.388	0.591	0.44 (0.25, 0.77)	0.004
	STAT3	rs3809758	17	37725506	Intron	A/G	0.119	0.031	4.18 (0.96, 18.2)	0.04
	PRKCSH	rs34095	19	11402685	Intron	T/C	0.365	0.625	0.35 (0.18, 0.64)	0.0005
Desipramine	CRHR2	rs917195	7	30694977	Flank	T/C	0.333	0.125	3.50 (1.24, 9.91)	0.01
	ABCB1	rs1202186	7	87051194	Intron	G/A	0.107	0.265	0.33 (0.12, 0.93)	0.03
	PSMD9	rs1043307	12	120838179	Missense	G/A	0.359	0.591	0.39 (0.19, 0.81)	0.01
	STAT3	rs3744483	17	37719964	3′ UTR	C/T	0.150	0.000	9.15 (1.44, ∞)	0.009
		rs3809758	17	37725506	Intron	A/G	0.171	0.000	11.28 (1.81, ∞)	0.005
	PRKCSH	rs34095	19	11402685	Intron	T/C	0.341	0.639	0.29 (0.13, 0.66)	0.002
Fluoxetine	CYP3A4	rs2242480	7	99199402	Intron	T/C	0.398	0.667	0.33 (0.13, 0.83)	0.02
	PSMD13	rs3817629	11	227312	Intron	T/C	0.170	0.000	6.17 (1.00, ∞)	0.04
	CD3E	rs2231449	11	117691515	3′ UTR	A/C	0.008	0.125	0.06 (0.01, 0.60)	0.002
	PRKCSH	rs160841	19	11420158	Intron	G/A	0.115	0.292	0.31 (0.11, 0.89)	0.02
	PSMA7	rs2057169	20	60145679	Intron	C/T	0.242	0.546	0.27 (0.11, 0.68)	0.004
		rs2057168	20	60145742	Intron	C/T	0.235	0.546	0.26 (0.10, 0.65)	0.003
		rs2281740	20	60145906	Intron	T/C	0.231	0.546	0.25 (0.10, 0.64)	0.002
		rs3746651	20	60151815	3′ UTR	C/T	0.230	0.500	0.30 (0.11, 0.79)	0.01

Abbreviations: SNPs, single nucleotide polymorphisms; UTR, untranslated region.

^aP-values, odds ratios (OR) and 95% confidence intervals (CI) were estimated on exact logistic regression model if any cell with the frequency is 0.