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. 2009 Mar 9;4(3):e4746. doi: 10.1371/journal.pone.0004746

Figure 5. Suppressor mutations from the prkaca-F327A background.

Figure 5

A, Highlighted suppressor mutations identified from the prkaca-F327A background. The original F327A mutation is highlighted in yellow, and suppressor mutations are shown in blue. PKA features are highlighted as follows: small lobe, gray; large lobe, sand; C-terminal tail,red; PKI: magenta. Some frequently highlighted mutations are labeled. The image was made using PDB file 1ATP and modeled using PyMol. B, Mutations isolated from the same suppressor are connected by a dashed line. Single suppressor mutations are listed above the corresponding secondary structural elements of PKA. Secondary structural elements are represented where alpha-helices are red and beta-sheets are blue.