Figure 3. Growth defect in Asxl2^−/− animals.

(A) Comparison of body weights at weaning (3 weeks) for wild-type (blue columns), heterozygous (green columns), runt mutant (red columns) and non-runt mutant (black columns) mice. Error bars stand for standard deviation. M: males. F: females. (B) Growth of wild-type (blue line), heterozygous (green line) and non-runt mutant (black line) animals. Body weights were measured every two weeks after weaning and plotted against time. Animals of all three genotypes gained weight over time, but the weight gap between non-runt mutants and wild-type or heterozygous animals widens from 3 to 5 weeks and remains wide throughout the time course of measurements. The growth curve of runt mutants was not generated because very few runt mutants were born and all died early.