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. 2009 Mar 9;4(3):e4754. doi: 10.1371/journal.pone.0004754

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Wiedemann et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Parietal cells were detected with anti-proton pump antibody in antral tissue (left panel), transition zone (middle panel), and corpus tissue (right panel) of non-infected Mongolian gerbils (original magnification 10×). (B) Immunohistochemical staining with anti-proton pump antibody detecting complete parietal cell atrophy in antral tissue at 64 weeks (left panel) and beginning at 8 weeks (middle panel) as well as complete parietal cell atrophy in corpus tissue at 16 weeks (right panel) of H. pylori B128 WT-infected gerbils. (C) Histological parietal cell atrophy grading of antral (white triangles) and corpus (gray triangles) mucosa infected with H. pylori B128 WT (upper panel) and B128ΔcagY isogenic mutant strain (bottom panel) over time. (*p<0.05).