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Interstitial potassium concentration, [KISF], in the gastrocnemius muscle of WT and α2R/R mice at rest and during maintained contractile activity. [KISF] was measured by microdialysis in anesthetized mice. Evoked isotonic contractions were elicited by stimulation of the sciatic nerve (70 Hz/250-ms tetanus applied at 1 Hz for 18 min). Dialysate was collected for 25 min before stimulation and in 6-min intervals during and after contraction.
