Fig. 5.

Residues adopt a similar conformation in both structures. (A and B) Sequence (A) and structure (B) alignment of both mutant and wild-type Iβ strands. Shifted side chains adopt conformations of wild-type residues despite changes in identity or sequence. This is clearly seen by residue C459, where in the wild-type conformation it is buried in the core but in the mutant conformation, it slips 3 residues, becoming solvent-exposed and filling the space occupied by T462.