Table 3.

Comparison of FOXO3A association statistics from Japanese, German, French and Dutch samples

Significantly associated SNPs in Japanese				SNPs in strong LD with Willcox' SNPs	r2	Significantly associated SNPs in Germans*							Significantly associated SNPs in French*			Significantly associated SNPs in Dutch*
SNP	Min AF controls	Min AF elderly	PCCA			Min AF controls	Min AF centenarians	PCCA†	Min AF LLI	PCCA‡	Min AF 95–99 years	PCCA§	Min AF controls	Min AF centenarians	PCCA	Min AF controls	Min AF cohort '87	PCCA
rs2802292	0.255	0.371	<0.0001	rs6911407	1	0.378	0.438	0.006	0.415	0.030	0.402	0.211
				rs768023	1	0.382	0.440	0.007	0.415	0.051	0.400	0.330	0.393	0.429	0.097
				rs2802288	1	0.385	0.445	0.006	0.417	0.058	0.402	0.384				0.354	0.365	ns
				rs2802290	1	0.387	0.444	0.010	0.417	0.081	0.401	0.458
rs2764264	0.248	0.347	0.0002	rs9400239	0.88	0.295	0.366	0.0007	0.331	0.025	0.311	0.389
rs13217795	0.248	0.340	0.0006	rs9400239	1	0.295	0.366	0.0007	0.331	0.025	0.311	0.389
				rs2153960	0.88											0.281	0.293	ns

Min AF, minor allele frequency; P_CCA, P value obtained from an allele-based case-control comparison, using a χ² test with 1 df; LD, linkage disequilibrium; LLI, entire sample; 95–110 years); ns, not significant. r², LD values from CEU HapMap data between the markers typed in Japanese men and SNPs typed in Germans, French and Dutch.

*Association statistics for SNPs typed in Germans, French, or Dutch that are in perfect or strong LD with significant SNPs typed in Japanese men.

^†P_CCA for centenarian sample.

^‡P_CCA for entire LLI sample.

^§P_CCA for nonagenarians.