Fig. 4.

Neurobehavioral studies of Dock7^mnlt/mnlt mice. (A) Tail suspension test. Mice are suspended by the tail and monitored for movement. Shown is the cumulative time spent immobile over the course of the trial. (B) Habituation of object exploration. Mice are placed into a field containing 3 plastic objects. Contacts with each object are measured over 5 min of time. Contacts for the 3 objects are averaged for each mouse. Three consecutive trials are performed. (C) Y maze test. The percentage of spontaneous alterations is the number of consecutive triplets of different arm choices out of the total number of arm choices. (D) Light/dark transfer test. Total time spent in the brightly lit compartment was measured (Left) and the total number of transitions between light and dark compartments were counted (Right). (E) Social interaction test. Sociability is measured as the number of entries into a chamber containing a stranger mouse. Differences between Dock7^mnlt/mnlt and C57BL/6J controls are not significant (females P = 0.0619). Social novelty measures the number of entries into a chamber containing a stranger mouse as opposed to a chamber containing a familiar mouse. C57BL/6J is depicted by open bars; Dock7^mnlt/mnlt is depicted by filled bars. Data are represented as means ± SEMs, n = 8.