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Signaling networks usurped by EGFR in GBM tumor cells. STAT3 and MEK/ERK are activated by EGFRWT but not EGFRvIII receptors. Ex vivo cultures of cells from the indicated tumor genotypes were starved for 24 hr and stimulated with 50 ng/ml of EGF for 5 min. Immunoblots of total cell lysates were probed with the indicated antibodies.
