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FSHR-1 expression in the intestine is necessary and sufficient for pathogen resistance. (A) Intestinal-specific RNAi of fshr-1 causes worms to be as sensitive to PA14 as systemic RNAi of fshr-1. (B) Wild-type FSHR-1 expressed from endogenous or intestinal promoters fully rescues the fshr-1(ok778) mutant phenotype. FSHR-1 expressed from a neuronal promoter only partially rescues the mutant phenotype.
