Fig. 2.

Subchronic MPTP treatment alters the Nrf2-ARE pathway. ARE-hPAP reporter mice were given MPTP, and mice were killed 7 days after the last MPTP dose. (A and B) Histochemical staining and hPAP activity assay were performed on the STR (A) and SN (B). (C) Quantitative PCR analyses of Nrf2, NQO1, HO-1, GCLC, and GCLM in STR and SN after vehicle or 30 mg/kg MPTP treatment. (D) NQO1 activity in the STR and the SN after vehicle or MPTP treatments (all data comprise groups totaling 8–10 animals). (Scale bar, 50 μm.) *, P < 0.05 compared with the vehicle-treated group.