Table 1. Endothelial nitric oxide synthase (eNOS) polymorphisms.
| Polymorphism | Location | Allelesˆ | Clinical rationale | References |
|---|---|---|---|---|
| −786 T>C | promoter | C, T | C allele associated with: post-SAH vasospasm, coronary artery vasospasm | 18-20, 24-28 |
| 894 G>T | exon 7 | T, G | T allele associated with: coronary artery disease, carotid atherosclerosis, myocardial infarction | 26, 29-33 |
| VNTR* | intron 4 | a, b | a allele associated with: coronary artery disease, myocardial infarction, cerebral aneurysm rupture, aortic aneurysm rupture | 21-23 |
*
27-base variable-number-tandem-repeat
ˆ
C, cytosine; T, thymine; G, guanine; a=4 repeats; b=5 or 6 repeats