Table 1.
Baseline clinical features, viral load, clustering subgroupings and acquired drug resistance of primary/recent HIV infections (PHI) diagnosed between 1997-2007.
| Baseline Characteristics | Sub Group | Year of PHI diagnosisa | |||
|---|---|---|---|---|---|
| 1997-2001 (n=112) |
2002-2003 (n=233) |
2004-2005 (n=275) |
2006-2007 (n=228) |
||
| Gender (% PHI) | Male | 92.9 | 87.9 | 93.0 | 92.9 |
| Female | 7.0 | 12.0 | 7.0 | 7.1 | |
| Age (yr) | Unique | 38.4 ± 1.0 | 38.4 ± 0.9 | 37.4 ± 0.9 | 39.9 ± 1.1 |
| Cluster | 36.3 ± 1.3 | 37.1 ± 0.8 | 36.9 ± 0.7 | 36.1 ± 0.8 | |
| Viral load (log copies/ml) | Unique | 4.6 ± 0.1 | 4.7 ± 0.1 | 4.5 ± 0.1 | 4.7 ± 0.1 |
| Cluster | 4.5 ± 0.2 | 4.7 ± 0.1 | 4.7 ± 0.1 | 4.8 ± 0.1 | |
| Risk group ( % PHI)b | MSM | 47.0 | 77.0 | 82.5 | 88.8 |
| IDU | 45.0 | 11.0 | 6.3 | 7.4 | |
| Heterosexual | 7.8 | 11.1 | 11.1 | 3.7 | |
| Cluster subgroup A c All PHI (% PHI) |
Unique | 50.4 | 46.4 | 42.8 | 43.0 |
| Small clusters (>5 PHI) |
30.9 | 24.6 | 28.0 | 28.5 | |
| Large clusters (≥5 PHI) |
18.5 | 28.8 | 28.4 | 28.1 | |
| Cluster subgroup B c Male only, non- IDU (% PHI)) |
Unique PHI | 50.0 | 49.3 | 49.8 | 50.0 |
| Small Clusters (mean PHI ± sem) |
26.9 (2.9 ± 0.3) |
23.7 (2.9 ± 0.1) |
24.2 (2.9 ± 0.1) |
25.6 (2.8 ± 0.1) |
|
| Large clusters (mean PHI ± sem) |
23.0 | 26.9 | 25.9 | 24.3 | |
| (11.9 ± 1.6) | (10.6 ± 0.7) | (14.3 ± 0.9) | (13.7 ± 1) | ||
| Drug Resistance (% PHI) |
Unique | 15.7 | 16.5 | 21.2 | 13.1 |
| Clustered | 33.9 | 16.8 | 13.0 | 18.5 | |
a
Baseline clinical characteristics of all genotyped PHI have been stratified according to year of diagnosis.
b
Risk group for participants in the PHI cohort study (n=249).
c
Cluster subgroup information is presented for all PHI (Cluster group A n=850), as well as for the male non-IDU subpopulation (n=730).
MSM, male-sex-male,; IDU-intravenous drug user