Figure 2.

Gross phenotype of Pkd^L/L embryos at different stages of development. Whole mounts of Pkd^L/L (B, D, F, H, J, and K) and age-matched WT embryos (A, C, E, G, and I) are shown. Localized hemorrhages and s.c. edema (arrows) distributed over the body surface, with punctate and localized hemorrhages seen in the head (B, D, and J) and toes (H and K) of Pkd1^L/L (J, H, and K) but not WT (A, C, E, G, and I) unstained embryos. At E15.5, fatal hemorrhages and edema are seen in Pkd^L/L embryos (H). Staged embryos were dissected in PBS and photographed by using a Leica MZ12 microscope.