Table 1.
Genotype and hemorrhagic phenotype of offspring from Pkd1L heterozygote crosses
| Stage | Pkd1+/+ | Pkd1+/L | Pkd1L/L | ND* | Total |
|---|---|---|---|---|---|
| 282 line | |||||
| E11.5 | 11 | 18 | 7 (0)† | 0 | 36 |
| E12.5 | 12 | 21 | 9 (3) | 2 | 43 |
| E13.5 | 15 | 17 | 12 (7) | 1 | 55 |
| E14.5 | 17 | 23 | 14 (8) | 2 | 56 |
| E15.5 | 12 | 19 | 9 (7) | 1 | 41 |
| E16.5 | 10 | 18 | 0 | 0 | 28 |
| E17.5 | 6 | 11 | 0 | 0 | 17 |
| Weanling | 16 | 29 | 0 | 0 | 45 |
| 130 line | |||||
| E11.5 | 7 | 14 | 5 (0)† | 0 | 26 |
| E12.5 | 10 | 14 | 5 (2) | 1 | 30 |
| E13.5 | 6 | 15 | 8 (4) | 1 | 29 |
| E14.5 | 12 | 18 | 7 (3) | 2 | 39 |
| E15.5 | 8 | 14 | 6 (5) | 1 | 29 |
| E16.5 | 6 | 10 | 0 | 0 | 16 |
| E17.5 | 5 | 9 | 0 | 0 | 14 |
| Weanling | 11 | 24 | 0 | 0 | 35 |
*ND, genotype not determined.
† The number of hemorrhagic phenotype is indicated in parentheses among homozygous mutants. All homozygous mutants had gross edema at every gestational age examined beyond E13.5.