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. 2009 Mar 9;4(3):e4736. doi: 10.1371/journal.pone.0004736

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Kobayashi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a) Flow cytometric analysis of BM from control and TRAF6-ΔB mice stained with the indicated antibodies (top-most and middle panels). The percentages of encircled areas are indicated. Pro+Pre, pro-B and pre-B cells; Imm, immature B cells; Rec, recirculating B cells. Results are representative of 5 mice. Lowest panel, absolute cell numbers; *, p<0.005. (b) Similar analysis of total spleen cells. Total B cells are shown in the topmost panels; mature (Mat) and immature (Imm) B cells are compared in the middle panels. The lowest panels compare the follicular (FO) and MZ sub-populations within the mature B cell gate shown in the middle panels. Cell numbers of each B cell subset in the spleen are shown in the lowest panels. Results are representative of at least 4 mice; *, p<0.05. (c) Splenic microarchitecture visualized by immunohistochemical staining with anti-B220 (red), anti-CD3 (blue) and anti-MOMA1 (green) antibodies. Results are representative of at least 5 mice.