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. Author manuscript; available in PMC: 2010 Jan 6.
Published in final edited form as: Cancer Cell. 2009 Jan 6;15(1):45–56. doi: 10.1016/j.ccr.2008.12.006

Table 1. Astrocytoma Formation in Tumor Suppressor Floxed Mice by Stereotactic Viral cre Injection.

Early postnatal or adult mutant mice were injected with cre adenovirus targeted to the SVZ or non-neurogenic brain regions such as the cortex and striatum. All adult SVZ-targeted mice developed tumors whereas mice targeted in the non-neurogenic regions did not.

Age at injection Experiment: Virus→target area tumor incidence/mice targeted
Early postnatal1 Cre→SVZ 10/10
Cre→other regions3 1/12
Controls5 0/8
Adult2 Cre→SVZ 12/12
Cre→other regions3,4 0/20
Controls5 0/9
1

Postnatal day 1–2;

2

4–8 weeks of age;

3

Other non-neurogenic regions targeted include the cortex and striatum;

4

9 out of 20 injections were intended SVZ injections that missed and did not result in LacZ+ SVZ-RMS-OB, 11 of 20 injections intentionally targeted cortex or striatum;

5

Controls include Ad-GFP injected into the SVZ or cortex/striatum of tumor suppressor mutant mice, and Ad-Cre injected into R26-lacZ mice alone