Table 2.

Association of NPY and NPY receptor genes and study phenotypes.

Gene	Id	SNP	Positiona	Locationb	MAFc	Alcohol Dependenced	Withdrawal Severed	Withdrawal Seizuresd	Cocaine Dependenced
NPY	1	rs12700524	24,287,939	Upstream	0.13	0.79	0.77	0.52	0.81
	2	rs16143	24,291,113	Intron 1	0.25	0.70	0.80	0.80	0.20
	3	rs16141	24,291,284	Intron 1	0.49	0.26	0.41	0.46	0.19
	4	rs16139	24,291,404	Exon 2, Pro7Leu	0.05	0.84	0.68	0.41	0.91
	5	rs5574	24,295,658	Exon 3, Ser68	0.49	0.39	0.73	0.73	0.42
	6	rs2023890	24,299,272	Downstream	0.23	0.73	0.80	0.41	0.63
	7	rs161416472	24,300,594	Downstream	0.09	0.31	0.82	0.14	0.25
NPY2R	1	rs2880414	156,313,101	Upstream	0.29	0.27	0.89	0.37	0.38
	2	rs4425326*	156,326,686	Upstream	0.36	0.03	0.03	0.35	0.02
	3	rs2880412	156,331,429	Upstream	0.26	0.60	0.88	0.52	0.15
	4	rs2342675	156,344,373	Upstream	0.35	0.53	0.58	0.46	0.03
	5	rs4333136	156,347,499	Upstream	0.38	0.02	0.08	0.60	0.004
	6	rs6857715*	156,348,632	Promoter	0.37	0.03	0.03	0.92	0.0005
	7	rs10461257	156,350,454	Intron 1	0.28	0.35	0.31	0.37	0.93
	8	rs10461238	156,351,666	Intron 1	0.40	0.71	0.41	0.32	0.08
	9	rs1574175	156,353,162	Intron 1	0.12	0.83	0.85	0.94	0.28
	10	rs2342674	156,354,700	Exon 2, Leu53	0.01	0.38	1.00	0.32	0.06
	11	rs1047214	156,355,126	Exon 2, Ile195	0.46	0.34	0.69	0.78	0.40
	12	rs2880415	156,355,477	Exon 2, Ile312	0.47	0.28	0.49	0.81	0.18
	13	rs17304901	156,357,822	Downstream	0.27	0.35	0.18	0.31	0.005
	14	rs9990860	156,359,515	Downstream	0.22	0.72	0.82	0.28	0.21
	15	rs2342652	156,361,5662	Downstream	0.48	0.81	0.12	0.61	0.76
NPY1R	1	rs1574637	164,461,542	Downstream	0.11	0.16	0.65	0.45	0.55
NPY1R	2	rs9764	164,464,855	3’ UTR	0.26	0.28	0.19	0.73	0.47
NPY1R	3	rs5578	164,465,939	Exon 3, Thr374Lys	0.01	0.89	0.32	0.32	0.78
NPY1R	4	rs5577	164,467,193	5’ UTR	0.02	0.87	0.94	0.65	0.79
NPY1R	5	rs4691075	164,468,935	Intron 1	0.12	0.15	0.63	0.38	0.67
NPY1R	6	rs11100489	164,472,262	Intron 1	0.10	0.25	0.85	0.54	0.75
NPY1R	7	rs4518200	164,473,872	Promoter	0.11	0.21	0.63	0.73	0.90
	8	rs6837793	164,476,185	Intergenic	0.11	0.24	0.51	0.56	0.73
	9	rs4234955	164,479,726	Intergenic	0.26	0.45	0.87	0.97	0.51
	10	rs4475104	164,482,736	Intergenic	0.11	0.67	0.33	0.05	0.56
NPY5R	11	rs9996227	164,483,251	Promoter	0.11	0.29	0.17	0.06	0.82
NPY5R	12	rs4314240	164,484,226	Promoter	0.11	0.87	0.20	0.05	0.34
NPY5R	13	rs4632602	164,486,579	Intron 2	0.12	0.42	0.33	0.008	0.75
NPY5R	14	rs7678265	164,488,364	Intron 3	0.09	0.22	0.55	0.02	0.33
NPY5R	15	rs7679206	164,488,684	Intron 3	0.23	0.09	0.21	0.36	0.86
NPY5R	16	rs11100494	164,489,703	Intron 3	0.07	0.89	0.38	0.75	0.81
NPY5R	17	rs11946004	164,492,153	Exon 4, Gly426	0.12	0.13	0.60	0.06	0.71

^aPosition in nucleotides, from NCBI Human Genome Assembly (version 36.2)

^bposition within or near gene.

^cMinor allele frequency calculated from the COGA dataset.

^dPedigree Disequilibrium test average statistic p-value. Bolded are significant (p≤0.05) association SNPs.

^*SNPs used in haplotype analysis.

NPY, Neuropeptide Y; COGA, Collaborative Study on the Genetics of Alcoholism; SNP, Single Nucleotide Polymorphism