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. Author manuscript; available in PMC: 2009 Oct 29.
Published in final edited form as: J Am Chem Soc. 2008 Oct 2;130(43):14022–14023. doi: 10.1021/ja8064667

Figure 1.

Figure 1

A. HPLC and MS analysis of cleaved reaction products as isoindole derivatives. Treatment of L-Ile-S-KtzC (1) with KtzD yields a chlorinated intermediate (2) which is dehydrochlorinated by KtzA (3). B. The biosynthetic pathway for allocoronamic acid tethered in thioester linkage to KtzC. A detailed mechanism is presented in scheme S1.