FIG. 1.

Amino acid sequence alignment among the 12 AmpC β-lactamases from AG3 (ADC-12 to -23) with respect to that of A. baumannii (ADC-1). Amino acid differences are indicated. The typical β-lactamase domains (SVSK, YSN, and KTG) and the Ω-loop are double underlined. The amino acid replacements present in at least four or more proteins (relative to that of ADC-1) with more than one residue are underlined. The vertical arrow indicates the position of the +1 amino acid (after cleavage of signal peptide). ADC-1, AmpC from A. baumannii (see reference 6).